Lifespan

This readthedocs contains the documentation for the Lifespan BrainChart project:

• bioRxiv pre-print

• GNU R Shiny App

• Peer-reviewed publication: PENDING

The corresponding GitHub repository also contains the objects necessary to reproduce the fitted curves, as seen in the article and web-app above.

This repository does not contain any of the datasets. We do not have permission to distributed many of the studies included within the published analyses. However, many are available upon request from the original study groups; see the relevant supplementary material for details of all the studies.

Check out the Usage section for further information Check out the Scripts section for further information Check out the Tutorial section for modelling walk-through on simulated data

Note

This project is under active development.

Contents

• Usage
  • Lifespan curve estimation (and uncertainty)
  • Extracting population curves
• Scripts
  • 1xx scripts: common
  • 2xx scripts: data setup
  • 3xx scripts:
  • 5xx scripts: plotting
• Tutorial
  • Model fitting (310-script) (SI 1.1, SI 1.3)
  • Model selection (320-script) (SI 1.3)
  • Model Uncertainty (330-script and 340-script) (SI 1.2)
  • Out-of-sample estimation (350-novel-script) (SI 1.8)
  • Derived values (350-derived-script) (SI 1.5, SI 1.7)
    • Normalised Centiles
    • Longitudinal Centiles
    • Population curves
  • Example plots